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To review the tolerability and diagnostic effectiveness of gadoteric acid under daily practice conditions in the general population and at-risk patients.

A total of 84,621 patients (45.4% men, 54.6% women, mean age 52.0±16.9 years) were studied in 129 German centers. Patients underwent contrast-enhanced magnetic resonance imaging (MRI) using gadoteric acid (Gd-DOTA, Dotarem^®, Guerbet, Roissy CdG, France) as IV contrast medium (mean volume, 16.4ml). 22.9% of the patients had at least one risk factor (e.g., allergies, previous allergic reaction to a contrast medium, and renal impairment). 554 patients received pretreatment before contrast medium administration (0.7%). Adverse events were documented and image quality was assessed.

A diagnosis was possible in 99.7% of all cases. Image quality was rated good or excellent in 97.1%. Adverse events …