作者
Miklós Fagyas, Zsolt Fejes, Renáta Sütő, Zsuzsanna Nagy, Borbála Székely, Marianna Pócsi, Gergely Ivády, Edina Bíró, Gabriella Bekő, Attila Nagy, György Kerekes, Zoltán Szentkereszty, Zoltán Papp, Attila Tóth, János Kappelmayer, Béla Nagy Jr
发表日期
2022/2/1
期刊
International Journal of Infectious Diseases
卷号
115
页码范围
8-16
出版商
Elsevier
简介
Objectives
Angiotensin-converting enzyme 2 (ACE2) represents the primary receptor for SARS-CoV-2 to enter endothelial cells. Here we investigated circulating ACE2 activity to predict the severity and mortality of COVID-19.
Methods
Serum ACE2 activity was measured in COVID-19 (110 critically ill and 66 severely ill subjects at hospital admission and 106 follow-up samples) and in 32 non-COVID-19 severe sepsis patients. Associations between ACE2, inflammation-dependent biomarkers, pre-existing comorbidities, and clinical outcomes were studied.
Results
Initial ACE2 activity was significantly higher in critically ill COVID-19 patients (54.4 [36.7-90.8] mU/L) than in severe COVID-19 (34.5 [25.2-48.7] mU/L; P<0.0001) and non-COVID-19 sepsis patients (40.9 [21.4-65.7] mU/L; P=0.0260) regardless of comorbidities. Circulating ACE2 activity correlated with inflammatory biomarkers and was further elevated during …
学术搜索中的文章
M Fagyas, Z Fejes, R Sütő, Z Nagy, B Székely, M Pócsi… - International Journal of Infectious Diseases, 2022