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Despite continuous advances in troponin assays, there is still significant room for improvement, particularly in the area of assay standardization and elimination of interferences and various preanalytical factors. The absolute concentrations of cTnI are currently not comparable between manufacturers because of the different antibodies used in the cTnI assays. Although many laboratories calibrate using National Institute of Standards and Technology standards to minimize interlaboratory variations, complete standardization would only be achieved if all manufacturers utilized the same antibodies, which is a difficult goal because of intellectual property and economic issues. In the absence of cTnI standardization, clinicians should not base clinical judgment on results obtained from different analyzers or laboratories.