作者
Eran Yanowski, Nancy S Yacovzada, Eyal David, Amir Giladi, Diego Jaitin, Lydia Farack, Adi Egozi, Danny Ben-Zvi, Shalev Itzkovitz, Ido Amit, Eran Hornstein
发表日期
2022/6/1
期刊
Molecular Metabolism
卷号
60
页码范围
101467
出版商
Elsevier
简介
Objectives
Until recently, communication between neighboring cells in islets of Langerhans was overlooked by genomic technologies, which require rigorous tissue dissociation into single cells.
Methods
We utilize sorting of physically interacting cells (PICs) with single-cell RNA-sequencing to systematically map cellular interactions in the endocrine pancreas after pancreatectomy.
Results
The pancreas cellular landscape features pancreatectomy associated heterogeneity of beta-cells, including an interaction-specific program between paired beta and delta-cells.
Conclusions
Our analysis suggests that the particular cluster of beta-cells that pairs with delta-cells benefits from stress protection, implying that the interaction between beta- and delta-cells might safeguard against pancreatectomy associated challenges. The work encourages testing the potential relevance of physically-interacting beta-delta-cells also in …
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E Yanowski, NS Yacovzada, E David, A Giladi, D Jaitin… - Molecular Metabolism, 2022