作者
Richard F Schlenk, S Fröhling, F Hartmann, J Th Fischer, A Glasmacher, F Del Valle, W Grimminger, K Götze, C Waterhouse, R Schoch, H Pralle, Hans-Guenther Mergenthaler, Manfred Hensel, Elisabeth Koller, Heinz Kirchen, J Preiss, H Salwender, HG Biedermann, Stephan Kremers, Frank Griesinger, Axel Benner, B Addamo, K Döhner, Rainer Haas, Hartmut Döhner
发表日期
2004/11
期刊
Leukemia
卷号
18
期号
11
页码范围
1798-1803
出版商
Nature Publishing Group
简介
The purpose of our study was (i) to evaluate the impact of all-trans retinoic acid (ATRA) given as adjunct to chemotherapy and (ii) to compare second consolidation vs maintenance therapy in elderly patients with acute myeloid leukemia (AML). A total of 242 patients aged⩾ 61 years (median, 66.6 years) with AML were randomly assigned to ATRA beginning on day+ 3 after the initiation of chemotherapy (ATRA-arm, n= 122) or no ATRA (standard-arm, n= 120) in combination with induction and first consolidation therapy. A total of 61 patients in complete remission (CR) were randomly assigned to second intense consolidation (n= 31) or 1-year oral maintenance therapy (n= 30). After induction therapy the intention-to-treat analysis revealed a significant difference in CR rates between the ATRA-and the standard-arm (52 vs 39%; P= 0.05). Event-free (EFS) and overall survival (OS) were significantly better in the ATRA …
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RF Schlenk, S Fröhling, F Hartmann, JT Fischer… - Leukemia, 2004