作者
Anatolii R Syniugin, Olga V Ostrynska, Maksym O Chekanov, Galyna P Volynets, Sergiy A Starosyla, Volodymyr G Bdzhola, Sergiy M Yarmoluk
发表日期
2016/11/4
期刊
Journal of Enzyme Inhibition and Medicinal Chemistry
卷号
31
期号
sup4
页码范围
160-169
出版商
Taylor & Francis
简介
In this article, the derivatives of 3-quinoline carboxylic acid were studied as inhibitors of protein kinase CK2. Forty-three new compounds were synthesized. Among them 22 compounds inhibiting CK2 with IC50 in the range from 0.65 to 18.2 μM were identified. The most active inhibitors were found among tetrazolo-quinoline-4-carboxylic acid and 2-aminoquinoline-3-carboxylic acid derivatives.
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AR Syniugin, OV Ostrynska, MO Chekanov… - Journal of Enzyme Inhibition and Medicinal Chemistry, 2016