作者
Yuxuan Luo, Nan Jiang, Herman I May, Xiang Luo, Anwarul Ferdous, Gabriele G Schiattarella, Guihao Chen, Qinfeng Li, Chao Li, Beverly A Rothermel, Dingsheng Jiang, Sergio Lavandero, Thomas G Gillette, Joseph A Hill
发表日期
2021/7/6
期刊
Circulation
卷号
144
期号
1
页码范围
34-51
出版商
Lippincott Williams & Wilkins
简介
Background
Cardiac hypertrophy is an independent risk factor for heart failure, a leading cause of morbidity and mortality globally. The calcineurin/NFAT (nuclear factor of activated T cells) pathway and the MAPK (mitogen-activated protein kinase)/Erk (extracellular signal-regulated kinase) pathway contribute to the pathogenesis of cardiac hypertrophy as an interdependent network of signaling cascades. How these pathways interact remains unclear and few direct targets responsible for the prohypertrophic role of NFAT have been described.
Methods
By engineering cardiomyocyte-specific ETS2 (a member of the E26 transformation-specific sequence [ETS] domain family) knockout mice, we investigated the role of ETS2 in cardiac hypertrophy. Primary cardiomyocytes were used to evaluate ETS2 function in cell growth.
Results
ETS2 is phosphorylated and activated by Erk1/2 on hypertrophic stimulation in both …
学术搜索中的文章
Y Luo, N Jiang, HI May, X Luo, A Ferdous… - Circulation, 2021