作者
Carolin Lerchenmüller, Ana Vujic, Sonja Mittag, Annie Wang, Charles P Rabolli, Chiara Heß, Fynn Betge, Ashraf Y Rangrez, Malay Chaklader, Christelle Guillermier, Frank Gyngard, Jason D Roh, Haobo Li, Matthew L Steinhauser, Norbert Frey, Beverly Rothermel, Christoph Dieterich, Anthony Rosenzweig, Richard T Lee
发表日期
2022/8/2
期刊
Circulation
卷号
146
期号
5
页码范围
412-426
出版商
Lippincott Williams & Wilkins
简介
Background
The human heart has limited capacity to generate new cardiomyocytes and this capacity declines with age. Because loss of cardiomyocytes may contribute to heart failure, it is crucial to explore stimuli of endogenous cardiac regeneration to favorably shift the balance between loss of cardiomyocytes and the birth of new cardiomyocytes in the aged heart. We have previously shown that cardiomyogenesis can be activated by exercise in the young adult mouse heart. Whether exercise also induces cardiomyogenesis in aged hearts, however, is still unknown. Here, we aim to investigate the effect of exercise on the generation of new cardiomyocytes in the aged heart.
Methods
Aged (20-month-old) mice were subjected to an 8-week voluntary running protocol, and age-matched sedentary animals served as controls. Cardiomyogenesis in aged hearts was assessed on the basis of 15N-thymidine …
学术搜索中的文章
C Lerchenmüller, A Vujic, S Mittag, A Wang, CP Rabolli… - Circulation, 2022