作者
Katarzyna Chawarska, Frederick Shic, Suzanne Macari, Daniel J Campbell, Jessica Brian, Rebecca Landa, Ted Hutman, Charles A Nelson, Sally Ozonoff, Helen Tager-Flusberg, Gregory S Young, Lonnie Zwaigenbaum, Ira L Cohen, Tony Charman, Daniel S Messinger, Ami Klin, Scott Johnson, Susan Bryson
发表日期
2014/12/1
期刊
Journal of the American Academy of Child & Adolescent Psychiatry
卷号
53
期号
12
页码范围
1317-1327. e1
出版商
Elsevier
简介
Objective
Younger siblings of children with autism spectrum disorder (ASD) are at high risk (HR) for developing ASD as well as features of the broader autism phenotype. Although this complicates early diagnostic considerations in this cohort, it also provides an opportunity to examine patterns of behavior associated specifically with ASD compared to other developmental outcomes.
Method
We applied Classification and Regression Trees (CART) analysis to individual items of the Autism Diagnostic Observation Schedule (ADOS) in 719 HR siblings to identify behavioral features at 18 months that were predictive of diagnostic outcomes (ASD, atypical development, and typical development) at 36 months.
Results
Three distinct combinations of features at 18 months were predictive of ASD outcome: poor eye contact combined with lack of communicative gestures and giving; poor eye contact combined with a lack of …
学术搜索中的文章
K Chawarska, F Shic, S Macari, DJ Campbell, J Brian… - Journal of the American Academy of Child & …, 2014
