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Nowadays mini-implant overdenture is widely used as a substitution for the conventional two-implant overdenture. More studies and assessments are needed to confirm this replacement. Thus, fourteen male patients were selected then categorized randomly into two groups. The first group received seven mandibular mini-implant overdentures retained by four single piece mini-implants. The second group received seven mandibular overdenture retained by two conventional size implant assembled with ball attachment. All patients were scheduled for recall visits at time of loading, six months and twelve months to measure marginal bone height, probing depth and gingival index. At six month, the first group showed higher mean values of both marginal bone height (0.758±0.141 mm) and probing depth (2.297±0.198 mm) than the second group with statistically significant difference at p< 0.05. At twelve month, the first group showed higher mean value also for marginal bone height (2.938±0.176 mm) with statistically significant difference at p< 0.05. The mean value of the pocket depth of the first group (2.896±0.140 mm) was higher than the second group with no statistical significance. Gingival index results showed a slight change between the two groups with no statistically significant difference. Although mini-implant overdenture is a successful treatment option for completely edentulous patients, the conventional two-implant overdenture showed advantageous radiographic and clinical outcomes.