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The main objective for developing implant surface modifications is to promote osseointegration, with faster and intimate contact bone formation. The purpose of this study is to assess histologically and histomorphometrically the role of surface characteristics and manufacturing technique of two unique dental implant systems. The first one relies on engraving the titanium surface using laser to produce nano-sized grooves, while the second depends on selective laser-sintering technique as an additive prototyping method. Twelve New Zealand white mature male rabbits weighting 2.5-4 kg were selected. Each rabbit received two implants, one in each tibia. Tapered internal Biohorizons implant (TIB) was placed in the right limb; whilst on the contralateral side Internal hex Tixos (IHT) was selected. Six rabbits were sacrificed after 4 weeks then the others after 8 weeks for histological and histomorphometrical assessment. The mean area percent filled by bone trabeculae 4 weeks post-operatively was greater in the TIB group (62.31±13.38) compared to the IHT group (59.38±12.15) with no statistically significant difference (p= 0.7263). On the contrary, eight weeks post-operatively, the area percent of bone trabeculae was greater in the IHT group (90.66±2.87) compared to the TIB group (83.3±3.92). With statistically high significant difference (p= 0.0095). Advances in the laser technology as a manufacturing tool leads to highly improved implant surface treatment and so enhanced oseointegration. According to the current study, the implant surface roughness created by selective laser sintering provided better environment for osseointegration than that …