作者
Edith A Nutescu, Sarah A Spinier, Ann Wittkowsky, William E Dager
发表日期
2009/6
来源
Annals of Pharmacotherapy
卷号
43
期号
6
页码范围
1064-1083
出版商
SAGE Publications
简介
Objective
To develop practical recommendations for the use of low-molecular-weight heparins (LMWHs) as prophylaxis and treatment of venous thromboembolism and acute coronary syndromes in patients with impaired renal function or obesity.
Data Sources
Multiple MEDLINE searches were performed (November 2008) to identify studies for inclusion, using a comprehensive list of search terms including, but not limited to, LMWH, enoxaparin, dalteparin, tinzaparin, obesity, weight, renal, kidney, elderly, monitoring, and anti-Xa.
Study Selection And Data Extraction
Only articles published in English that were relevant for this review were included.
Data Synthesis
In the majority of patients, standardized prophylaxis or treatment doses of LMWHs can be used without the need for monitoring and adjusting regimens. For patients with severe renal impairment (estimated creatinine clearance [CrCl] <30 mL/min), doses of …
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EA Nutescu, SA Spinier, A Wittkowsky, WE Dager - Annals of Pharmacotherapy, 2009
