作者
Harumi Takahashi, Grant R Wilkinson, Edith A Nutescu, Takashi Morita, Marylyn D Ritchie, Maria G Scordo, Vittorio Pengo, Martina Barban, Roberto Padrini, Ichiro Ieiri, Kenji Otsubo, Toshitaka Kashima, Sosuke Kimura, Shinichi Kijima, Hirotoshi Echizen
发表日期
2006/2/1
期刊
Pharmacogenetics and genomics
卷号
16
期号
2
页码范围
101-110
出版商
LWW
简介
Objective
To investigate pharmacokinetic and pharmacodynamic factors associated with population differences in warfarin doses needed to achieve anticoagulation, in particular the possible involvement of genetic variability in vitamin K epoxide reductase (VKOR) and CYP2C9.
Methods
Warfarin maintenance dose, unbound plasma S-warfarin concentration [Cu (S)] and INR were determined in 157 Caucasians, 172 Japanese, and 36 African-Americans stably anticoagulated patients. In a subset (n= 166), fully carboxylated plasma normal prothrombin levels (NPT) were also measured. Genotyping for seven CYP2C9 (CYP2C9* 1 through 6 and* 11) and seven VKORC1 variants were performed in 115 Caucasians and 64 Japanese patients and 66 healthy African-Americans. Multivariate analysis was performed to identify covariates associated with warfarin requirement.
Results
The relationship between NPT and Cu (S …
引用总数
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H Takahashi, GR Wilkinson, EA Nutescu, T Morita… - Pharmacogenetics and genomics, 2006
