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Objectives of the study: Non-steroidal anti-inflammatory drugs (NSAIDs) belong to a group of drugs used in the management of pain. The aim of this study is to assess dentists’ knowledge of NSAIDs risks and to determine the most prescribed NSAIDs by dentists.

Materials and Methods: We collected information concerning the dentists’ knowledge of NSAIDs use and adverse effects. A questionnaire consisting of 22 questions was distributed to 123 Albanian dentists reached in different dental clinics, out of which only 87 agreed to participate. Only 70.73% of the distributed questionnaires were completed.

Results: Respondents demonstrated poor knowledge of NSAIDs. Most of the respondents did not respond correctly to the questions with 39.08% of incorrect answers regarding the implications of NSAIDs in elderly patients and only 3.44% responded correctly to the contraindication of NSAIDs. The most common prescriptions were ketoprofen, ibuprofen, followed by ketorolac, aspirin, and diclofenac.

Conclusions: Dentists who participated in the survey have limited knowledge of NSAIDs use, contraindication, and safety limitation which can affect patients’ safety and well-being. Dentists should pay particular attention to informing patients on NSAIDs use and should also keep updated on NSAIDs, through continuing education programs.