作者
Wen Hui Lim, Cheng Han Ng, Darren Jun Hao Tan, Jieling Xiao, Clarissa Elysia Fu, Christen Ong, Benjamin Koh, Charlotte Chung, Shi Ni Tan, Zhen Yu Wong, Kimberly Mitchell, Ayana Andrews Joseph, Michael Tseng, Nicholas Syn, Lung Yi Mak, James Fung, Daniel Q Huang, Mark Muthiah, Eunice XX Tan, Mohammad Shadab Siddiqui
发表日期
2024/2/1
期刊
Transplantation
卷号
108
期号
2
页码范围
473-482
出版商
LWW
简介
Background.
Liver transplantation (LT) offers patients with decompensated cirrhosis the best chance at long-term survival. With the rising prevalence of diabetes, further clarity is needed on the impact of receiving a liver allograft from a donor with diabetes on post-LT outcomes. This study aims to evaluate the impact of donor diabetes on clinical outcomes after LT.
Methods.
This is a retrospective analysis of the United Network for Organ Sharing registry data of LT recipients from January 1, 2000, to December 31, 2021. Outcomes analysis was performed using Cox proportional model for all-cause mortality and graft failure. Confounding was reduced by coarsened exact matching causal inference analysis.
Results.
Of 66 960 donors identified, 7178 (10.7%) had diabetes. Trend analysis revealed a longitudinal increase in the prevalence of donor diabetes (P< 0.001). Importantly, donor diabetes was associated with …
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WH Lim, CH Ng, DJH Tan, J Xiao, CE Fu, C Ong, B Koh… - Transplantation, 2024