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Background: Methicillin-Resistant Staphylococcus aureus (MRSA) has been contributing to nosocomial infections ever since 1961. In Malaysia, there was an increase in the MRSA rate from 18% in 2016 to 19.8% in 2017.

Materials and Methods: In our study, we determined the prevalence, the risk factor of developing MRSA infection and investigate the prognosis in surgical wards, for all adult patients (> 18 years old) with MRSA bacteremia who was admitted to the Hospital Tuanku Jaafar (HTJ), from January 2018 to December 2018, we focused on surgical departments only as previous studies done for all hospital departments medical and surgical.

Results: In our study, the prevalence of MRSA is 8.53% in surgical wards, from a total of 598 patients were isolated with staphylococcus aureus 51 patients' specimens were detected with MRSA infection. Risk factors include older patients aged more than 60 years, prolonged duration of hospitalization, history of antibiotic use in the past and comorbidities such as chronic kidney disease, hypertension, and diabetes mellitus represent 5.9%, 47.1% and 35.3% respectively, with mortality rate 11.76%.

Conclusion: Our explanations for low percentage in surgical departments comparison to other specialties, that is most probably due to applications of the infection control measures including hand hygiene, personal protection equipment, isolation of antibiotic-resistant cases, also, applications of guideline for prevention of surgical site infection issued by Ministry of Health, Malaysia, which includes shortening the hospital staying duration, chlorhexidine bath the night before surgery, Enhanced Recovery after …