作者
Jieling Xiao, Cheng Han Ng, Kai En Chan, Clarissa Fu, Phoebe Tay, Jie Ning Yong, Wen Hui Lim, Darren Jun Hao Tan, Nicholas Syn, Zhen Yu Wong, Michael Tseng, Nicholas Chew, Daniel Q Huang, Yock Yong Dan, Vincent Wai-Sun Wong, Rohit Loomba, Mohammad S Siddiqui, Arun J Sanyal, Mazen Noureddin, Mark D Muthiah
发表日期
2023/7/1
来源
Journal of Clinical and Experimental Hepatology
卷号
13
期号
4
页码范围
656-665
出版商
Elsevier
简介
Background
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease globally. While the prevalence, impact, and causes of mortality have been described in various meta-analyses, a systematic all-encompassing umbrella review has yet to be conducted to consolidate the evidence on outcomes associated with NAFLD.
Methods
Search was conducted on Medline and Embase for meta-analysis investigating associated complications and causes of mortality in NAFLD patients. Summary estimates were presented with original units, sample size, and I2 for heterogeneity. The Assessment of Multiple Systematic Reviews 2 was employed for article selection.
Results
25 meta-analyses were included in the present review. NAFLD increased the risks of systemic complications, including cardiovascular diseases, systemic malignancies, diabetes, and chronic kidney disease. Regarding hepatic …
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