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COI notes: ET has received honoraria from Abbvie, Roche, Janssen-Cilag and research support from AbbVie, Gilead and Roche. RR has received honoraria from Abbvie, AstraZeneca, Janssen, Illumina and Roche. PG has received research support from AbbVie, AstraZeneca, Gilead, Janssen, Sunesis; has received honoraria from AbbVie, ArQule/MSD, AstraZeneca, BeiGene, Celgene/Juno/BMS, Janssen, Lilly/Loxo, Roche. VM was an employee of Gilead Sciences, Inc.,(during the time of the study) and reports stockownership of Gilead Sciences, Inc., and AstraZeneca (current employment; outside the submitted work), and family member is an employee of Gilead Sciences, Inc. SS has received advisory board honoraria, research support, travel support and speaker fees from AbbVie, Amgen, AstraZeneca, Celgene, Gilead, GSK, Hoffmann-La Roche, Janssen, Novartis and Sunesis.