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Studies in recent years have revealed that increasing age is associated with the accumulation of post-zygotic genetic aberrations in different cell lineages even in the absence of active malignancy. Clonal hematopoiesis of indeterminate potential (CHIP) is defined as the detection of somatic mutations in genes commonly associated with myeloid neoplasms in the peripheral blood of individuals with no sign of hematological malignancy. The process of CHIP derives from ageing hematopoietic stem cells that have accumulated mutations, rendering proliferative advantage compared with their peers, resulting in clonal expansion [1, 2]. CHIP is an age-related phenomenon, regularly observed in healthy older individuals at frequencies up to 10% at age 70 years. CHIP has been associated with increased risk of hematological malignancies as well as cardiovascular diseases [1–3]. In parallel, peripheral leukocytes often …