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Loneliness can be operationalized as the actual or perceived absence of those social relationships that serve to meet basic emotional needs. In contrast to solitude, a chosen state of being without company, loneliness is associated with negative affect and emotional distress. Loneliness can have detrimental effects on mental and physical wellbeing, expressed as an increased risk of morbidity and mortality. Higher rates of loneliness are observed in patients suffering from chronic health conditions, mental health conditions, cardiovascular problems, and neurodivergent populations, including autistic individuals. While the link between poor health and loneliness is established, the identification of relevant underlying mechanisms is a difficult endeavor. In this narrative review, we provide an overview of published research and related literature describing the manifold interactions between loneliness, affective …