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1, 3, 4-Oxadiazoles have been reported to posses a variety of activities like antianxiety1, antidepressant2, antiinflammatory3, antimicrobial and antifungal4-8 activities. As a continuation of our research program on biologically active heterocyclic, we synthesized new compounds bearing an azomethine linkage and evaluated in vitro their antimicrobial and antifungal activities. This paper reports the evaluation of new Schiff bases (azomethine) bearing furan and substituted phenyl substituents.