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Methods

We conducted the literature search in MEDLINE, EMBASE, the Cochrane Register of Controlled Trials, Web of Knowledge, and CINAHL databases, until July 20, 2014. We included RCTs comparing thrombolysis to anticoagulation alone and those comparing different types of thrombolytic agents in patients who had objectively confirmed symptomatic PE. We applied no limitations to language, publication date, patient age, or gender. We searched major international hematology and cardiology conference proceedings and abstracts in the past 10 years. Supplemental Appendix 2 lists the detailed search strategies. After selecting a final list of studies for data extraction, 3 authors (T.-FW, AS, and FD) independently reviewed each study and extracted data according to a predefined protocol. Discordances were resolved by consensus.