作者
Lin Xu, Joshua L Pierce, Angelica Sanchez, Kenneth S Chen, Abhay A Shukla, Nicholas J Fustino, Sarai H Stuart, Aditya Bagrodia, Xue Xiao, Lei Guo, Mark D Krailo, Furqan Shaikh, Deborah F Billmire, Farzana Pashankar, Jessica Bestrashniy, J Wolter Oosterhuis, Ad JM Gillis, Yang Xie, Lisa Teot, Jaume Mora, Jenny N Poynter, Dinesh Rakheja, Leendert HJ Looijenga, Bruce W Draper, A Lindsay Frazier, James F Amatruda
发表日期
2023/5/6
期刊
Nature communications
卷号
14
期号
1
页码范围
2636
出版商
Nature Publishing Group UK
简介
Germ cell tumors (GCTs) are neoplasms of the testis, ovary and extragonadal sites that occur in infants, children, adolescents and adults. Post-pubertal (type II) malignant GCTs may present as seminoma, non-seminoma or mixed histologies. In contrast, pre-pubertal (type I) GCTs are limited to (benign) teratoma and (malignant) yolk sac tumor (YST). Epidemiologic and molecular data have shown that pre- and post-pubertal GCTs arise by distinct mechanisms. Dedicated studies of the genomic landscape of type I and II GCT in children and adolescents are lacking. Here we present an integrated genomic analysis of extracranial GCTs across the age spectrum from 0–24 years. Activation of the WNT pathway by somatic mutation, copy-number alteration, and differential promoter methylation is a prominent feature of GCTs in children, adolescents and young adults, and is associated with poor clinical outcomes …
学术搜索中的文章
L Xu, JL Pierce, A Sanchez, KS Chen, AA Shukla… - Nature communications, 2023