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Marek's disease (MD) in the chicken, caused by the highly infectious MD α‐herpesvirus (MDV), is both commercially important and a unique, naturally occurring model for human T‐cell lymphomas overexpressing the Hodgkin's disease antigen, CD30. Here, we used proteomics as a basis for modeling the molecular functions and biological processes involved in MDV‐induced lymphomagenesis. Proteins were extracted from an MDV‐transformed cell line and were then identified using 2‐D LC‐ESI‐MS/MS. From the resulting 3870 cellular and 21 MDV proteins we confirm the existence of 3150 “predicted” and 12 “hypothetical” chicken proteins. The UA‐01 proteome is proliferative, differentiated, angiogenic, pro‐metastatic and pro‐immune‐escape but anti‐programmed cell death, ‐anergy, ‐quiescence and ‐senescence and is consistent with a cancer phenotype. In particular, the pro‐metastatic integrin signaling …