作者
Angkawipa Trongtorsak, Sittinun Thangjui, Jakrin Kewcharoen, Natchaya Polpichai, Ratdanai Yodsuwan, Veraprapas Kittipibul, Harvey J Friedman, Alfonso Q Estrada
发表日期
2021/11/19
来源
Acta cardiologica
卷号
76
期号
9
页码范围
933-942
出版商
Taylor & Francis
简介
Background
Current guidelines recommend vitamin K antagonists (VKAs) to reduce the risk of systemic thromboembolic (STE) events in patients with left ventricular (LV) thrombus. Direct oral anticoagulants (DOACs) are an emerging alternative to VKAs; however, data supporting DOAC use in LV thrombus are still lacking. We conducted this systematic review and meta-analysis to compare the efficacy and safety between DOACs and VKAs in this population.
Methods
We searched MEDLINE, Embase, and the Cochrane Library databases from inception to October 2020 to identify studies that compared clinical outcomes of interest, including stroke or any STE, LV thrombus resolution, and bleeding, between patients who used DOACs and VKAs for LV thrombus. Data from each study were combined using the random-effects model.
Results
Eight cohort studies with a total of 1771 patients (426 in DOAC group, 1345 in …
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A Trongtorsak, S Thangjui, J Kewcharoen, N Polpichai… - Acta cardiologica, 2021