作者
Arnold S Bayer, Paul M Sullam, Marcelo Ramos, Cong Li, Ambrose L Cheung, Michael R Yeaman
发表日期
1995/9
期刊
Infection and immunity
卷号
63
期号
9
页码范围
3634-3641
简介
Platelet aggregation by bacteria is felt to play an important role in the pathogenesis of infective endocarditis. However, the mechanisms involved in bacterium-induced platelet aggregation are not well-defined. In the present study, we examined the mechanisms by which Staphylococcus aureus causes rabbit platelet aggregation in vitro. In normal plasma, the kinetics of S. aureus-induced platelet aggregation were rapid and biphasic. The onset and magnitude of aggregation phase 1 varied with the bacterium-platelet ratio, with maximal aggregation observed at a ratio of 5:1. The onset of aggregation phase 2 was delayed in the presence of apyrase (an ADP hydrolase), suggesting that this later aggregation phase may be triggered by secreted ADP. The onset of aggregation phase 2 was delayed in the presence of prostaglandin I2-treated platelets, and this phase was absent when paraformaldehyde-fixed platelets …
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AS Bayer, PM Sullam, M Ramos, C Li, AL Cheung… - Infection and immunity, 1995