作者
Joerg Overhage, Andrea Campisano, Manjeet Bains, Ellen CW Torfs, Bernd HA Rehm, Robert EW Hancock
发表日期
2008/9
期刊
Infection and immunity
卷号
76
期号
9
页码范围
4176-4182
出版商
American Society for Microbiology
简介
The ability to form biofilms is a critical factor in chronic infections by Pseudomonas aeruginosa and has made this bacterium a model organism with respect to biofilm formation. This study describes a new, previously unrecognized role for the human cationic host defense peptide LL-37. In addition to its key role in modulating the innate immune response and weak antimicrobial activity, LL-37 potently inhibited the formation of bacterial biofilms in vitro. This occurred at the very low and physiologically meaningful concentration of 0.5 μg/ml, far below that required to kill or inhibit growth (MIC = 64 μg/ml). LL-37 also affected existing, pregrown P. aeruginosa biofilms. Similar results were obtained using the bovine neutrophil peptide indolicidin, but no inhibitory effect on biofilm formation was detected using subinhibitory concentrations of the mouse peptide CRAMP, which shares 67% identity with LL-37, polymyxin B, or …
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J Overhage, A Campisano, M Bains, ECW Torfs… - Infection and immunity, 2008