作者
S Lilly Zheng, Jielin Sun, Fredrik Wiklund, Shelly Smith, Pär Stattin, Ge Li, Hans-Olov Adami, Fang-Chi Hsu, Yi Zhu, Katarina Bälter, A Karim Kader, Aubrey R Turner, Wennuan Liu, Eugene R Bleecker, Deborah A Meyers, David Duggan, John D Carpten, Bao-Li Chang, William B Isaacs, Jianfeng Xu, Henrik Grönberg
发表日期
2008/2/28
期刊
New England Journal of Medicine
卷号
358
期号
9
页码范围
910-919
出版商
Massachusetts Medical Society
简介
Background
Single-nucleotide polymorphisms (SNPs) in five chromosomal regions — three at 8q24 and one each at 17q12 and 17q24.3 — have been associated with prostate cancer. Each SNP has only a moderate association, but when SNPs are combined, the association may be stronger.
Methods
We evaluated 16 SNPs from five chromosomal regions in a Swedish population (2893 subjects with prostate cancer and 1781 control subjects) and assessed the individual and combined association of the SNPs with prostate cancer.
Results
Multiple SNPs in each of the five regions were associated with prostate cancer in single SNP analysis. When the most significant SNP from each of the five regions was selected and included in a multivariate analysis, each SNP remained significant after adjustment for other SNPs and family history. Together, the five SNPs and family history were estimated to account for 46 …
引用总数
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SL Zheng, J Sun, F Wiklund, S Smith, P Stattin, G Li… - New England Journal of Medicine, 2008
