作者
AA Badawy, NM El-Badrawy, SS Mansy, MM Akl, AM Abdel Hady, FA Ebeid, MM Hassan
发表日期
1996/6/1
期刊
Pharmacological research
卷号
33
期号
6
页码范围
319-325
出版商
Academic Press
简介
Colchicine alone or following praziquantel was given to mice infected withSchistosoma mansonieither 6 or 10 weeks post infection. Praziquantel increased body weight gain, histologically reduced number, diameter and cellularity of granuloma and improved liver function parameters. Early praziquantel therapy decreased hepatic collagen content as detected by the colorimetric method and the serum procollagen propeptide (PIIIP), while later treatment at the 10th week of infection increased hepatic collagen content and serum PIIIP. Colchicine therapy significantly decreased body weight gain with significant weight loss after early treatment. Colchicine did not change the histologic picture of schistosomal liver fibrosis; it induced a detectable hepatocytic injury recorded ultrastructurally and histologically with excitation of the inflammatory reaction in the granuloma and in portal tracts after early treatment. Excess …
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