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We consider two different skin structure models. The first structure consists of epidermis, dermis/blood, and subcutaneous tissue. The second structure consists of epidermis/dermis, adipose tissue and muscle tissue. A new solution based on diffusion theory of the cw local diffuse reflectance from a three-layered skin tissue structure is presented. Comparisons with Monte Carlo simulations are carried out favorably. It is shown that the functional form of the radial dependence of the diffuse reflectance from multilayer and single layer models are identical. We use a modified expression originating from diffusion theory to fit the diffuse reflectance. We discuss the sensitivity of the local diffuse reflectance as a function of the optical properties of separate layers in both structures. Moreover, we investigate the influence on the local diffuse reflectance with changes in the optical properties corresponding to normal changes in …