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Purpose: To organize the properties of safety culture addressed by many studies and to develop a conceptual culture of safety model.

Design and Methods: A comprehensive review of the culture of safety literature within the U.S. hospital setting. The review was a qualitative meta‐analysis from which we generated a conceptual culture of safety framework and developed a typology of the safety culture literature.

Findings: Seven subcultures of patient safety culture were identified: (a) leadership, (b) teamwork, (c) evidence‐based, (d) communication, (e) learning, (f) just, and (g) patient‐centered.

Conclusions: Safety culture is a complex phenomenon that is not clearly understood by hospital leaders, thus making it difficult to operationalize. We found senior leadership accountability key to an organization‐wide culture of safety.

Clinical Relevance: Hospital leaders are increasingly pressured by federal, state …