作者
Mahsa M Amoli, Shirin Hasani-Ranjbar, Nahid Roohipour, Forough A Sayahpour, Parvin Amiri, Parisa Zahedi, Mahdie Mehrab-Mohseni, Ramin Heshmat, Bagher Larijani, Javad Tavakkoly-Bazzaz
发表日期
2011/8/1
期刊
Diabetes research and clinical practice
卷号
93
期号
2
页码范围
215-219
出版商
Elsevier
简介
OBJECTIVE
Functional polymorphisms within vascular endothelial growth factor (VEGF) gene have shown association with various conditions including diabetic neuropathy and retinopathy. In this study we have performed a candidate gene association study in order to examine VEGF gene polymorphism association with diabetic foot ulcer (DFU).
METHODS
The study group comprised of type 2 diabetes patients with (N=247) and without (N=241) DFU. Healthy control subjects (N=98) were also recruited from the same area. The ARMS-PCR technique was applied for genotyping of VEGF gene SNPs at positions −7*C/T and −2578*C/A.
RESULTS
The frequency of genotype AA was significantly decreased in patients with DFU compared with diabetic subjects without DFU (AA vs CA+CC, p=0.003, OR=0.44, CI=0.24–0.80). Also there was a significant decrease in frequency of A allele in patients with DFU compared to …
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MM Amoli, S Hasani-Ranjbar, N Roohipour… - Diabetes research and clinical practice, 2011