作者
Tsutomu Takahashi, Mark Walterfang, Stephen J Wood, Matthew J Kempton, Jigar Jogia, Valentina Lorenzetti, Bridget Soulsby, Michio Suzuki, Dennis Velakoulis, Christos Pantelis, Sophia Frangou
发表日期
2010/8/1
期刊
Journal of affective disorders
卷号
124
期号
3
页码范围
256-261
出版商
Elsevier
简介
BACKGROUND
Hypothalamic–pituitary–adrenal (HPA) axis dysregulation has been reported in bipolar disorder (BD), but previous magnetic resonance imaging (MRI) studies of pituitary gland volume in BD have yielded inconsistent findings. In addition, the contribution of genetic factors to the pituitary changes in BD remains largely unknown.
METHOD
We used MRI to investigate the pituitary volume in 29 remitted patients with BD, 49 of their first-degree relatives (of whom 15 had a diagnosis of Major Depressive Disorder), and 52 age- and gender-matched healthy controls.
RESULTS
BD patients had a significantly larger pituitary volume compared with their relatives and healthy controls. Pituitary volume did not differ between controls and healthy relatives or relatives diagnosed with major depression.
LIMITATIONS
Direct measures of HPA function (i.e., hormonal levels) were not available.
CONCLUSIONS
These …
学术搜索中的文章
T Takahashi, M Walterfang, SJ Wood, MJ Kempton… - Journal of affective disorders, 2010