作者
Florian Keller, Georgios Psychogios, Rainer Linke, Michael Lell, Torsten Kuwert, Heinrich Iro, Johannes Zenk
发表日期
2011/11
期刊
Head & neck
卷号
33
期号
11
页码范围
1569-1575
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Background
Comparison of the diagnostic validity of positron emission tomography (PET) alone with integrated PET and CT (PET/CT) in the search for occult primary tumors in patients with cancer of unknown primary (CUP) site in the head and neck.
Methods
Thirty‐nine consecutive patients with clinical CUP were investigated with PET and 38 patients with PET/CT. After initial diagnostic panendoscopy and histological confirmation of the cervical lymph node metastasis, either PET or PET/CT scanning was performed.
Results
Integrated PET/CT had a significantly higher overall detection rate than dedicated PET alone (55.2% vs 30.8%; p = .039) and positive prediction rate (93.3% vs 46.1%; p = .01).
Conclusion
Integrated PET/CT showed to be superior to PET in the detection of the primary site of clinically occult tumors in CUP syndrome. However, a negative result should still be investigated further by means of …
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F Keller, G Psychogios, R Linke, M Lell, T Kuwert, H Iro… - Head & neck, 2011