作者
Rebecca L Ursin, Santosh Dhakal, Hsuan Liu, Sahana Jayaraman, Han-Sol Park, Harrison R Powell, Morgan L Sherer, Kirsten E Littlefield, Ashley L Fink, Zexu Ma, Alice L Mueller, Allison P Chen, Kumba Seddu, Yishak A Woldetsadik, Patricia J Gearhart, H Benjamin Larman, Robert W Maul, Andrew Pekosz, Sabra L Klein
发表日期
2022/8/30
期刊
MBio
卷号
13
期号
4
页码范围
e01839-22
出版商
American Society for Microbiology
简介
Inactivated influenza vaccines induce greater antibody responses in females than males among both humans and mice. To test the breadth of protection, we used recombinant mouse-adapted A/California/2009 (maA/Cal/09) H1N1 viruses containing mutations at one (1M), two (2M), or three (3M) antigenic sites, in addition to a virus containing the 1M mutation and a substitution of the Ca2 antigenic site (Sub) with one derived from an H5 hemagglutinin (HA) to challenge mice of both sexes. Following maA/Cal/09 vaccination, females produced greater virus-specific, class-switched total IgG and IgG2c antibodies against the vaccine and all mutant viruses, and antibodies from females recognized a greater number of unique, linear HA epitopes than did antibodies from males. While females had greater neutralizing antibody titers against the vaccine virus, both sexes showed a lower neutralization capacity against …
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RL Ursin, S Dhakal, H Liu, S Jayaraman, HS Park… - MBio, 2022