作者
Sonu Subudhi, Hannah K Drescher, Laura E Dichtel, Lea M Bartsch, Raymond T Chung, Matthew M Hutter, Denise W Gee, Ozanan R Meireles, Elan R Witkowski, Louis Gelrud, Ricard Masia, Stephanie A Osganian, Jenna L Gustafson, Steve Rwema, Miriam A Bredella, Sangeeta N Bhatia, Andrew Warren, Karen K Miller, Georg M Lauer, Kathleen E Corey
发表日期
2022/1
期刊
Hepatology Communications
卷号
6
期号
1
页码范围
77-89
简介
Approaches to manage nonalcoholic fatty liver disease (NAFLD) are limited by an incomplete understanding of disease pathogenesis. The aim of this study was to identify hepatic gene‐expression patterns associated with different patterns of liver injury in a high‐risk cohort of adults with obesity. Using the NanoString Technologies (Seattle, WA) nCounter assay, we quantified expression of 795 genes, hypothesized to be involved in hepatic fibrosis, inflammation, and steatosis, in liver tissue from 318 adults with obesity. Liver specimens were categorized into four distinct NAFLD phenotypes: normal liver histology (NLH), steatosis only (steatosis), nonalcoholic steatohepatitis without fibrosis (NASH F0), and NASH with fibrosis stage 1‐4 (NASH F1‐F4). One hundred twenty‐five genes were significantly increasing or decreasing as NAFLD pathology progressed. Compared with NLH, NASH F0 was characterized by …
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S Subudhi, HK Drescher, LE Dichtel, LM Bartsch… - Hepatology Communications, 2022