作者
Courtney E Collins, Elan R Witkowski, Julie M Flahive, Fred A Anderson Jr, Heena P Santry
发表日期
2014/10/1
期刊
The American Journal of Surgery
卷号
208
期号
4
页码范围
544-549. e1
出版商
Elsevier
简介
Background
Elderly Americans are at increased risk of head trauma, particularly fall related. The effect of warfarin on head trauma outcomes remains controversial.
Methods
Medicare beneficiaries with head injuries from 2009 to 2011 were identified by International Classification of Diseases (ICD)-9 code. Preinjury warfarin use was determined using Part D claims. Multiple logistic regression models determined the association of preinjury warfarin on need for hospitalization, intensive care unit care, and occurrence of intracranial hemorrhage. Association between warfarin and in-hospital mortality was assessed using a Cox proportional hazard model.
Results
Of 11,078 head injured patients, 5.2% were injured while on warfarin. Preinjury warfarin increased the odds of intracranial hemorrhage by 40% and doubled the risk of 30-day in-hospital mortality after adjusting for demographic and clinical factors.
Conclusions …
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CE Collins, ER Witkowski, JM Flahive, FA Anderson Jr… - The American Journal of Surgery, 2014