作者
Nicolás Nin, Adriana Cassina, José Boggia, Evangelina Alfonso, Horacio Botti, Gonzalo Peluffo, Andrés Trostchansky, Carlos Batthyány, Rafael Radi, Homero Rubbo, F Javier Hurtado
发表日期
2004/12
期刊
Intensive care medicine
卷号
30
页码范围
2271-2278
出版商
Springer-Verlag
简介
Objective
Decreased diaphragmatic contractility and organ failure observed during sepsis is mediated by an overproduction of nitric oxide (.NO)-derived species, mitochondria being a major target of oxidative and nitrative stress. We tested the potential protective effects of (a) a novel synthetic antioxidant, the manganese(III) 5,10,15,20-tetrakis(N-ethylpyridinium-2-yl) porphyrin (MnTE-2-PyP5+) and (b) the inducible .NO synthase inhibitor aminoguanidine (AG) on a rat model of sepsis.
Setting
University research laboratories.
Subjects and interventions
Sepsis was induced by cecal ligation and perforation in rats.
Measurements and results
Systemic hemodynamics, pulmonary gas exchange, in vitro diaphragmatic function and mitochondrial respiration were evaluated. Moreover, plasma …
引用总数
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学术搜索中的文章
N Nin, A Cassina, J Boggia, E Alfonso, H Botti… - Intensive care medicine, 2004