作者
Núria Rodríguez de Dios, Felipe Couñago, Mauricio Murcia-Mejía, Mikel Rico-Oses, Patricia Calvo-Crespo, Pilar Samper, Carmen Vallejo, Javier Luna, Itziar Trueba, Amalia Sotoca, Cristina Cigarral, Núria Farré, Rosa M Manero, Xavier Durán, Juan Domigo Gispert, Gonzalo Sánchez-Benavides, Teresa Rognoni, Margarita Torrente, Jaume Capellades, Mar Jiménez, Teresa Cabada, Miguel Blanco, Ana Alonso, Juan Martínez-San Millán, José Escribano, Beatriz González, José Luis López-Guerra
发表日期
2021/10/1
期刊
Journal of Clinical Oncology
卷号
39
期号
28
页码范围
3118-3127
出版商
Wolters Kluwer Health
简介
PURPOSE
Radiation dose received by the neural stem cells of the hippocampus during whole-brain radiotherapy has been associated with neurocognitive decline. The key concern using hippocampal avoidance-prophylactic cranial irradiation (HA-PCI) in patients with small-cell lung cancer (SCLC) is the incidence of brain metastasis within the hippocampal avoidance zone.
METHODS
This phase III trial enrolled 150 patients with SCLC (71.3% with limited disease) to standard prophylactic cranial irradiation (PCI; 25 Gy in 10 fractions) or HA-PCI. The primary objective was the delayed free recall (DFR) on the Free and Cued Selective Reminding Test (FCSRT) at 3 months; a decrease of 3 points or greater from baseline was considered a decline. Secondary end points included other FCSRT scores, quality of life (QoL), evaluation of the incidence and location of brain metastases, and overall survival (OS). Data were …
学术搜索中的文章
N Rodríguez de Dios, F Couñago, M Murcia-Mejía… - Journal of Clinical Oncology, 2021