作者
Russell A Poldrack, Timothy O Laumann, Oluwasanmi Koyejo, Brenda Gregory, Ashleigh Hover, Mei-Yen Chen, Krzysztof J Gorgolewski, Jeffrey Luci, Sung Jun Joo, Ryan L Boyd, Scott Hunicke-Smith, Zack Booth Simpson, Thomas Caven, Vanessa Sochat, James M Shine, Evan Gordon, Abraham Z Snyder, Babatunde Adeyemo, Steven E Petersen, David C Glahn, D Reese Mckay, Joanne E Curran, Harald HH Göring, Melanie A Carless, John Blangero, Robert Dougherty, Alexander Leemans, Daniel A Handwerker, Laurie Frick, Edward M Marcotte, Jeanette A Mumford
发表日期
2015/12/9
期刊
Nature communications
卷号
6
期号
1
页码范围
8885
出版商
Nature Publishing Group UK
简介
Psychiatric disorders are characterized by major fluctuations in psychological function over the course of weeks and months, but the dynamic characteristics of brain function over this timescale in healthy individuals are unknown. Here, as a proof of concept to address this question, we present the MyConnectome project. An intensive phenome-wide assessment of a single human was performed over a period of 18 months, including functional and structural brain connectivity using magnetic resonance imaging, psychological function and physical health, gene expression and metabolomics. A reproducible analysis workflow is provided, along with open access to the data and an online browser for results. We demonstrate dynamic changes in brain connectivity over the timescales of days to months, and relations between brain connectivity, gene expression and metabolites. This resource can serve as a testbed to …
学术搜索中的文章
RA Poldrack, TO Laumann, O Koyejo, B Gregory… - Nature communications, 2015