作者
Marieke Langen, Alexander Leemans, Patrick Johnston, Christine Ecker, Eileen Daly, Clodagh M Murphy, Flavio dell’Acqua, Sarah Durston, Declan GM Murphy, AIMS Consortium
发表日期
2012/2/1
期刊
Cortex
卷号
48
期号
2
页码范围
183-193
出版商
Elsevier
简介
INTRODUCTION
Repetitive behaviour and inhibitory control deficits are core features of autism; and it has been suggested that they result from differences in the anatomy of striatum; and/or the ‘connectivity’ of subcortical regions to frontal cortex. There are few studies, however, that have measured the micro-structural organisation of white matter tracts connecting striatum and frontal cortex.
AIMS
To investigate differences in bulk volume of striatum and micro-structural organisation of fronto-striatal white matter in people with autism; and their association with repetitive behaviour and inhibitory control.
METHODS
We compared the bulk volume of striatum (caudate nucleus, putamen and nucleus accumbens) and white matter organisation of fronto-striatal tracts using (respectively) structural magnetic resonance imaging (sMRI) and tract specific diffusion tensor imaging (DTI) measures in 21 adults with autism and 22 …
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M Langen, A Leemans, P Johnston, C Ecker, E Daly… - Cortex, 2012