作者
Elliot Stein, William Fearon, Sammy Elmariah, Juyong Kim, Samir Kapadia, Dharam Kumbhani, Linda Gillam, Brian Whisenant, Nishath Quader, Alan Zajarias, Frederick Welt, Anthony Bavry, Megan Coylewright, Robert Piana, Ravinder Mallugari, Deepak Gupta, Anna Vatterott, Natalie- Jackson, Shi Huang, Brian Lindman
发表日期
2021/5/11
期刊
Journal of the American College of Cardiology
卷号
77
期号
18_Supplement_1
页码范围
1730-1730
出版商
American College of Cardiology Foundation
简介
Background
Left ventricular hypertrophy (LVH) is associated with increased mortality after transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS). Whether biomarkers of cardiac damage (cTnT) and stretch (NTproBNP) risk stratify patients with significant LVH is unknown.
Methods
In a multicenter prospective registry of 925 patients with severe AS undergoing TAVR, we included 674 (mean age 82±8 yrs, 44% female, mean STS score was 5.3±3.6) with core-lab-measured LV mass index (LVMi), plasma cTnT, and NTproBNP. LVH was defined by sex-specific guideline cut-offs and elevated biomarker levels were based on age and sex cut-offs. Cox PH models for mortality were adjusted for age, sex, and STS score.
Results
Moderate or severe LVH was present in 210 (31%). The 5-year KM-estimated mortality tended to be higher among patients with mod/severe LVH vs. no/mild LVH (69.6% vs. 58.1 …
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E Stein, W Fearon, S Elmariah, J Kim, S Kapadia… - Journal of the American College of Cardiology, 2021