作者
Amos Baruch, Nicholas van Bruggen, Juyong Brian Kim, Joshua E Lehrer-Graiwer
发表日期
2013/6
来源
Current Atherosclerosis Reports
卷号
15
页码范围
1-11
出版商
Springer US
简介
Despite dramatic advances in standard of care, the risk of recurrent myocardial infarction early after an acute coronary syndrome (ACS) remains high. This period of elevated risk after a cardiovascular event is associated with an acute inflammatory response. While post-ACS inflammation correlates with the risk for recurrent events and is likely to play a causal role in this period, the precise pathophysiologic mechanisms have been unclear. Recent studies have proposed that the cardiac event itself activates the sympathetic nervous system to directly mobilize hematopoietic stem cells to differentiate into inflammatory monocytes, acutely infiltrate plaque, and lead to recurrent plaque rupture. Here, we summarize the existing and emerging evidence implicating post-ACS activation of systemic inflammation in the progression of atherosclerosis, and identify possible targets for therapeutic intervention. We highlight …
学术搜索中的文章
A Baruch, N van Bruggen, JB Kim, JE Lehrer-Graiwer - Current Atherosclerosis Reports, 2013