作者
Yvonne J Huang, Craig E Nelson, Eoin L Brodie, Todd Z DeSantis, Marshall S Baek, Jane Liu, Tanja Woyke, Martin Allgaier, Jim Bristow, Jeanine P Wiener-Kronish, E Rand Sutherland, Tonya S King, Nikolina Icitovic, Richard J Martin, William J Calhoun, Mario Castro, Loren C Denlinger, Emily DiMango, Monica Kraft, Stephen P Peters, Stephen I Wasserman, Michael E Wechsler, Homer A Boushey, Susan V Lynch, National Heart, Lung, and Blood Institute
发表日期
2011/2/1
期刊
Journal of Allergy and Clinical Immunology
卷号
127
期号
2
页码范围
372-381. e3
出版商
Mosby
简介
BACKGROUND
Improvement in lung function after macrolide antibiotic therapy has been attributed to reduction in bronchial infection by specific bacteria. However, the airway might be populated by a more diverse microbiota, and clinical features of asthma might be associated with characteristics of the airway microbiota present.
OBJECTIVE
We sought to determine whether relationships exist between the composition of the airway bacterial microbiota and clinical features of asthma using culture-independent tools capable of detecting the presence and relative abundance of most known bacteria.
METHODS
In this pilot study bronchial epithelial brushings were collected from 65 adults with suboptimally controlled asthma participating in a multicenter study of the effects of clarithromycin on asthma control and 10 healthy control subjects. A combination of high-density 16S ribosomal RNA microarray and parallel clone …
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YJ Huang, CE Nelson, EL Brodie, TZ DeSantis… - Journal of Allergy and Clinical Immunology, 2011