作者
Frank B Sachse, AP Moreno, G Seemann, JA Abildskov
发表日期
2009/5
期刊
Annals of biomedical engineering
卷号
37
页码范围
874-889
出版商
Springer US
简介
Fibroblasts are abundant in cardiac tissue. Experimental studies suggested that fibroblasts are electrically coupled to myocytes and this coupling can impact cardiac electrophysiology. In this work, we present a novel approach for mathematical modeling of electrical conduction in cardiac tissue composed of myocytes, fibroblasts, and the extracellular space. The model is an extension of established cardiac bidomain models, which include a description of intra-myocyte and extracellular conductivities, currents and potentials in addition to transmembrane voltages of myocytes. Our extension added a description of fibroblasts, which are electrically coupled with each other and with myocytes. We applied the extended model in exemplary computational simulations of plane waves and conduction in a thin tissue slice assuming an isotropic conductivity of the intra-fibroblast domain. In simulations of plane waves …
学术搜索中的文章
FB Sachse, AP Moreno, G Seemann, JA Abildskov - Annals of biomedical engineering, 2009