作者
Chun‐Yu Liu, Po‐Min Chen, Tzeon‐Jye Chiou, Jin‐Hwang Liu, Jen‐Kou Lin, Tzu‐Chen Lin, Wei‐Shone Chen, Jeng‐Kae Jiang, Huann‐Sheng Wang, Wei‐Shu Wang
发表日期
2008/5/1
期刊
Cancer
卷号
112
期号
9
页码范围
1932-1940
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
BACKGROUND
It is known that the uridine‐diphosphoglucuronosyl transferase 1A1 (UGT1A1)*28 polymorphism reduces UGT1A1 enzyme activity, which may lead to severe toxicities in patients who receive irinotecan. This study was conducted to assess the influence of this polymorphism on the efficacy and toxicity of irinotecan treatment in Chinese patients with metastatic colorectal carcinoma (CRC).
METHODS
In total, 128 patients with metastatic CRC who had received previous treatment with irinotecan plus 5‐fluorouracil/leucovorin were analyzed retrospectively. Genomic DNA samples were obtained from patients' leukocytes, and genotypes were determined by analyzing the sequence of TATA boxes in the UGT1A1 gene. The influence of the UGT1A1*28 polymorphism on toxicity and treatment outcome was analyzed.
RESULTS
Approximately 20% of patients were identified with the UGT1A1*28 …
引用总数
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