作者
Tatsuo Kanno, M Florian Mette, David P Kreil, Werner Aufsatz, Marjori Matzke, Antonius JM Matzke
发表日期
2004/5/4
期刊
Current Biology
卷号
14
期号
9
页码范围
801-805
出版商
Elsevier
简介
In plants, the mechanism by which RNA can induce de novo cytosine methylation of homologous DNA is poorly understood. Cytosines in all sequence contexts become modified in response to RNA signals [1, 2]. Recent work has implicated the de novo DNA methyltransferases (DMTases), DRM1 and DRM2, in establishing RNA-directed methylation of the constitutive nopaline synthase promoter [3], as well as the DMTase MET1 [4] and the putative histone deacetylase HDA6 [5] in maintaining or enhancing CpG methylation induced by RNA. Despite the identification of enzymes that catalyze epigenetic modifications in response to RNA signals, it is unclear how RNA targets DNA for methylation. A screen for mutants defective in RNA-directed DNA methylation identified a novel putative chromatin-remodeling protein, DRD1. This protein belongs to a previously undefined, plant-specific subfamily of SWI2/SNF2-like …
引用总数
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T Kanno, MF Mette, DP Kreil, W Aufsatz, M Matzke… - Current Biology, 2004