作者
Magaiver Andrade-Silva, Luana Barbosa Correa, André Luis Peixoto Candéa, Simone C Cavalher-Machado, Helene Santos Barbosa, Elaine Cruz Rosas, Maria G Henriques
发表日期
2016/11
期刊
Inflammation Research
卷号
65
页码范围
869-879
出版商
Springer International Publishing
简介
Objective and design
β-Caryophyllene (BCP) is a sesquiterpene that binds to the cannabinoid 2 (CB2) receptor and exerts anti-inflammatory effects. In this study, we investigated the anti-inflammatory effect of BCP and another CB2 agonist, GP1a in inflammatory experimental model induced by Mycobacterium bovis (BCG).
Methods
C57Bl/6 mice were pretreated orally with BCP (0.5–50 mg/kg) or intraperitonealy with GP1a (10 mg/kg) 1 h before the induction of pleurisy or pulmonary inflammation by BCG. The direct action of CB2 agonists on neutrophils function was evaluated in vitro.
Results
β-Caryophyllene (50 mg/kg) impaired BCG-induced neutrophil accumulation in pleurisy without affecting mononuclear cells or the production of TNF-α and CCL2/MCP-1. However, BCP inhibited CXCL1/KC, leukotriene B4 (LTB4), IL …
学术搜索中的文章
M Andrade-Silva, LB Correa, ALP Candéa… - Inflammation Research, 2016