作者
Natália Cristina Gomes-da-Silva, Luana Barbosa Corrêa, Mariana Martínez González, Álefe Roger Silva França, Luciana Magalhães Rebelo Alencar, Elaine Cruz Rosas, Eduardo Ricci-Junior, Tawanny Kayonara Borges Aguiar, Pedro Noronha Souza Filho, Ralph Santos-Oliveira
发表日期
2024
期刊
Current Medicinal Chemistry
出版商
Bentham Science Publishers
简介
Introduction
Nanoceria is a well-known nanomaterial with various properties, including antioxidant, proangiogenic, and therapeutic effects. Despite its potential, there are still aspects that require further exploration, particularly its anti-inflammatory and antimicrobial activities.
Method
The global demand for novel anti-inflammatory and antimicrobial drugs underscores the significance of understanding nanoceria in both contexts. In this study, we evaluated the effect of nanoceria on macrophage polarization to better understand its anti-inflammatory effects. Additionally, we investigated the mechanism of action of nanoceria against Cryptococcus neoformans (ATCC 32045), Candida parapsilosis (ATCC 22019), Candida krusei (ATCC 6258), and Candida albicans.
Result
The results demonstrated that nanoceria can polarize macrophages toward an anti-inflammatory profile, revealing the cellular mechanisms involved in …
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NC Gomes-da-Silva, LB Corrêa, MM González… - Current Medicinal Chemistry, 2024