作者
Giun-Yi Hung, Hsiu-Ju Yen, Chueh-Chuan Yen, Wei-Ming Chen, Paul Chih-Hsueh Chen, Hung-Ta Hondar Wu, Hong-Jen Chiou, Wan-Hui Chang, Hsiu-E Hsu
发表日期
2015/4
期刊
Annals of Surgical Oncology
卷号
22
页码范围
1080-1087
出版商
Springer US
简介
Purpose
To identify the prognostic factors and evaluate the impact of chemotherapy regimens on the outcomes of pediatric osteosarcoma of the extremities.
Methods
Patients younger than 18 years and diagnosed with high-grade osteosarcoma of the extremities during the period between January 2004 and December 2011 were included for retrospective analysis. Demographic characteristics and tumor features were compared between nonmetastatic and metastatic patients. Univariate analyses of overall survival (OS) and progression-free survival (PFS) were performed to evaluate the efficacy of various chemotherapy regimens.
Results
A total of 74 patients (58 with nonmetastatic and 16 with metastatic disease) were enrolled and treated with three protocols consisting of various cycles of high-dose methotrexate …
学术搜索中的文章
GY Hung, HJ Yen, CC Yen, WM Chen, PCH Chen… - Annals of Surgical Oncology, 2015
